The news is particularly disappointing given that Apple announced. To continue to use your tablet uninterrupted, Wacom suggests not to upgrade to 10.13 until the new driver is released. This problem is occurs on Windows 7 with Wacom tablet driver V6.1.2 installed, this may occur with other version of driver or software combinations.

Due to nature of the changes in High Sierra, the existing Wacom driver for 10.12 will not work. It seems that 14.04 will support the new Intuoses out of the box, by the way. The new Wacom driver will be ready by late October at the latest. It happens because of Windows Ink being enabled. The difference between 'working' and 'working including hotplugging' is that if I unplug and tablet and plug it back in, the buttons don't work until I run the script again. You may face this issue when using the Wacom Tablet Pen on Windows for EZOfficeInventory.

The script for the Wacom Manga submitted by a user at the end of the thread got the buttons on my P&T working once I added made that script executable and added it to my Startup Applications. Getting the tablet working in general is easy getting the buttons working including hotplugging is fiddly and I never succeeded at it.

If I understand correctly and you're using one of the new models like me, you'll want to pay close attention to the P&T-specific instructions in post 3 of the thread. The need to manually patch and compile the kernel support may sound frightening at first, but by carefully following the instructions, I succeeded at this as a relative layman. I have an Intuos Pen&Touch Medium (CTH-680) and was able to get it working in 13.10 using the information here:

Wacom tablet stabilizer not working